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Interaction-Based Simulations for Integrative Spatial Systems Biology : Application to the Simulations of a Synthetic Multicellular Organism in MGS

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article
 

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Titre

Interaction-Based Simulations for Integrative Spatial Systems Biology
 

Sous-Titre

Application to the Simulations of a Synthetic Multicellular Organism in MGS
 

Nom(s)

Giavitto, Jean-Louis (auteur)
 
Spicher, Antoine (auteur)
 
Michel, Olivier (auteur)
 

Publication

Springer, 2011
 

Description

Sujet(s)

systems biology   computational biology   modeling   simulation   Interaction-Based Simulations   Domain-Specific Languages   Rule- Based Modeling   Integrative Spatial Systems Biology   Synthetic Biology.
 

Résumé

Systems biology aims at integrating processes at various time and spatial scales into a single and coherent formal description to allow analysis and computer simulation. In this context, we focus on rule-based modeling and its integration in the domain-specific language MGS. Through the notions of topological collections and transformations, MGS allows the modeling of biological processes at various levels of description. We validate our approach through the description of various models of a synthetic bacteria designed in the context of the iGEM competition, from a very simple biochemical description of the process to an individual-based model on a Delaunay graph topology. This approach is a first step into providing the requirements for the emerging field of spatial systems biology which integrates spatial properties into systems biology.
 

Note(s)

Article paru dans : Understanding the Dynamics of Biological Systems - Lessons Learned from Integrative Systems Biology
 

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Date de la notice

2011-10-26 02:00:00
 

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